Natsume has announced that they will be bringing a new Harvest Moon to the 3DS later this year. Harvest Moon: The Lost Valley will again feature the farming and role-playing elements of its predecessors, as well as be the first 3D entry in the series. Customization will also be a focus, with players (slash farmers slash adventurers) capable of personalizing the world and fields. Additional details will be revealed at E3.
Harvest Moon: The Lost Valley is scheduled to launch later this year for 3DS.
Official Site: Natsume.com